Center of Integrated Biomedical and Bioengineering Research

Friday, September 27, 2019
12:10 PM - 1:00 PM
Rudman Hall G89
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Ricardo Rajsbaum, Ph.D, Associate Professor, Department of Microbiology & Immunology, University of Texas Medical Branch

"Regulation of innate immunity and virus replication by the host ubiquitin system"

The innate immune response involves activation of multiple signaling pathways that culminate in the production of type I interferons (IFN-I) and inflammatory cytokines, which together control virus infections. However, excessive cytokine production can result in exacerbated disease. To strike the right balance, these signaling pathways are regulated by different molecular processes, including the ubiquitin system. We will discuss novel molecular mechanism by which ubiquitin enzymes regulate host antiviral pathways, and how completely different pathogenic viruses (Nipah, Ebola, Zika and Influenza) repurpose the ubiquitin system to enhance virus replication. 

Co-sponsored by the Constance L. Rollins Fund 

Dr. R. Rajsbaum
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